THE ANTIMUTAGENIC EFFECT OF MULTIFLORAL HONEY IN SALMONELLA/ MICROSOMAL ASSAY AND ITS CORRELATION WITH THE TOTAL POLYPHENOLIC CONTENT

The objective of this study is to determine the antimutagenic effect honey and its correlation with concentration total polyphenolic content. Seven samples were collected from different regions Algeria. content was determined by Folin-Ciocalteu colorimetric assay. carried out AMES Salmonella/ microsome mutagenicity assay against three known mutagenic substances (4-nitro-o-phenylenediamine, sodium azide, mitomycin C), using Salmonella typhimurium TA98, TA100, TA102 strains. results obtained revealed that Algerian contains high polyphenol content, which varied significantly between 38.04 286.28 µg GAE/100 mg honey. This variation due their botanical regional origins. In addition, all tested exhibited an substances; effective inhibit 29.18±11.11 % 73.14±11.14 activity chemical substances. There a strong positive proprieties suggest as agent; it can play important role in protection DNA caused